Aldactone (spironolactone)

Aldactone (spironolactone)

Aldactone has been shown to cause tumors in laboratory animals. Aldactone should only be used for the conditions in which it is indicated. Avoid unnecessary use of Aldactone.

Aldactone is used for:

Treating swelling and fluid retention inpatients with congestive heart failure, cirrhosis, or kidney problems (nephrotic syndrome). It is also used for treatment of high blood pressure. It may also be used to treat or prevent low blood potassium. It may also be used to treat excess secretion of the hormone aldosterone by the adrenal gland.

Aldactone is a potassium-sparing diuretic. It works by blocking the hormone aldosterone, causing the kidney to eliminate excess water, save potassium, and lower blood pressure.

Do NOT use Aldactone if:

    * you are allergic to any ingredient in Aldactone
    * you are unable to urinate, have severe kidney problems, or have high blood potassium levels
    * you are taking a potassium supplement, another potassium-sparing diuretic (eg, amiloride, triamterene), or another aldosterone-blocker (eg, eplerenone)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Aldactone:

Some medical conditions may interact with Aldactone. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

    * if you are pregnant, planning to become pregnant, or are breast-feeding
    * if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
    * if you have allergies to medicines, foods, or other substances
    * if you have high acidity in your body fluids; low sodium levels in your blood; liver, heart, or lung disease; diabetes; or high urea or nitrogen in your blood
    * if you have menstrual disease

Some MEDICINES MAY INTERACT with Aldactone. Tell your health care provider if you are taking any other medicines, especially any of the following:

    * Corticosteroids (eg, prednisone) or ACTH because low blood electrolyte levels may occur
    * Barbiturates (eg, phenobarbital) or narcotics (eg, morphine) because dizziness upon standing may occur
    * Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), angiotensin II receptor antagonists (eg, valsartan), cyclosporine, macrolide immunosuppressives (eg, tacrolimus), other potassium sparing diuretics (eg, amiloride, triamterene), other aldosterone-blockers (eg, eplerenone), or potassium supplements because high blood potassium levels may occur (eg, listlessness, confusion, abnormal skin sensations of the arms and legs, heaviness of limbs, slowed heart rate, irregular heart rhythm, potentially life-threatening slow or irregular heartbeat)
    * Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, indomethacin) because they may decrease Aldactone's effectiveness and increase the risk of kidney problems and high blood potassium
    * Digoxin, digitoxin, lithium, nondepolarizing muscle relaxants (eg, tubocurarine), or quinidine because the risk of their side effects and toxicity may be increased by Aldactone
    * Pressor amines (eg, norepinephrine) because their effectiveness may be decreased by Aldactone

This may not be a complete list of all interactions that may occur. Ask your health care provider if Aldactone may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Aldactone:

Use Aldactone as directed by your doctor. Check the label on the medicine for exact dosing instructions.

    * Take Aldactone by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
    * Aldactone may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.
    * If you miss a dose of Aldactone, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If more than one dose is missed, restart the medication and advise your doctor or pharmacist at your next appointment.

Ask your health care provider any questions you may have about how to use Aldactone.

Important safety information:

    * Aldactone may cause dizziness and drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Aldactone with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
    * Aldactone can raise your body's potassium levels. This is more likely to occur in people with kidney problems, diabetes, in the elderly, or if the patient is severely ill. Potassium levels must be closely monitored in people with any of these problems or illnesses. If not treated, high potassium levels can be fatal.
    * Check with your doctor before you use a salt substitute or a product that has potassium in it.
    * Lab tests, including kidney function, blood pressure, blood potassium, and chemistries, may be performed while you use Aldactone. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
    * PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Aldactone while you are pregnant. Aldactone is found in breast milk. Do not breast-feed while taking Aldactone.

Possible side effects of Aldactone:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

    Abdominal cramping; change in sexual ability; clumsiness; confusion; diarrhea; dizziness; drowsiness; headache; frequent urination; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

    Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); breast tenderness; deepening of voice; dry mouth; enlarged breasts in men; excessive thirst; irregular or lack of menstrual periods; skin rash; slow, irregular, or fast heartbeat; ulcers; unusual muscle weakness; unusual tiredness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects.

If OVERDOSE is suspected:

Contact your local poison control center or emergency room immediately. Symptoms may include: lightheadedness; nausea; vomiting; weakness.
Proper storage of Aldactone:

Store Aldactone at room temperature, between 59 and 77 degrees F (15 and 25 degrees C), in a tightly closed container, away from heat, moisture, and light. Do not store in the bathroom. Keep Aldactone out of the reach of children and away from pets.

General information:

    * If you have any questions about Aldactone, please talk with your doctor, pharmacist, or other health care provider.
    * Aldactone is to be used only by the patient for whom it is prescribed. Do not share it with other people.
    * If your symptoms do not improve or if they become worse, check with your doctor.

This information is summary only. It does not contain all information about Aldactone. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other healthcare provider.

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